Platelets from patients with visceral obesity promote colon cancer growth

Marica Cariello; Elena Piccinin; Emanuela Pasculli; Maria Arconzo; Roberta Zerlotin; Simona D’Amore; Francesca Mastropasqua; Claudia Peres; Giusi Graziano; Gaetano Villani; Graziano Pesole; Antonio Moschetta

doi:10.1038/s42003-022-03486-7

Communications Biology (Jun 2022)

Platelets from patients with visceral obesity promote colon cancer growth

Marica Cariello,
Elena Piccinin,
Emanuela Pasculli,
Maria Arconzo,
Roberta Zerlotin,
Simona D’Amore,
Francesca Mastropasqua,
Claudia Peres,
Giusi Graziano,
Gaetano Villani,
Graziano Pesole,
Antonio Moschetta

Affiliations

Marica Cariello: Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari
Elena Piccinin: Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari
Emanuela Pasculli: Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari
Maria Arconzo: Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari
Roberta Zerlotin: Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari
Simona D’Amore: Department of Medicine, Addenbrookes Hospital, University of Cambridge, Box 157, Hills Rd
Francesca Mastropasqua: Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet, and Center for Psychiatry Research
Claudia Peres: INBB, National Institute for Biostructures and Biosystems
Giusi Graziano: INBB, National Institute for Biostructures and Biosystems
Gaetano Villani: Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari
Graziano Pesole: Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR)
Antonio Moschetta: Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari

DOI: https://doi.org/10.1038/s42003-022-03486-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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Platelets from patients with visceral obesity, which highly express miR-19a, can strongly promote colon cancer growth in a xenograft colon cancer model, with miR-19a administration by AAV injection increasing tumor growth.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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