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Repairing the Osteochondral Defect in Goat with the Tissue-Engineered Osteochondral Graft Preconstructed in a Double-Chamber Stirring Bioreactor

BioMed Research International. 2014;2014 DOI 10.1155/2014/219203


Journal Homepage

Journal Title: BioMed Research International

ISSN: 2314-6133 (Print); 2314-6141 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Medicine

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML



Yang Pei (School of Public Health, Fourth Military Medical University, No. 17 Changle Road, Xi’an 710032, China)

Jun-jun Fan (Department of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, No. 15 Changle Road, Xi’an 710032, China)

Xiao-qiang Zhang (Department of Orthopaedic Surgery, Southern Hospital, Southern Medical University, No. 1838 North Guangzhou Road, Guangzhou 510515, China)

Zhi-yong Zhang (Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, Shanghai Key Laboratory of Tissue Engineering, School of Medicine, Shanghai Jiao Tong University, Shanghai 200040, China)

Min Yu (School of Public Health, Fourth Military Medical University, No. 17 Changle Road, Xi’an 710032, China)


Blind peer review

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Instructions for authors

Time From Submission to Publication: 19 weeks


Abstract | Full Text

To investigate the reparative efficacy of tissue-engineered osteochondral (TEO) graft for repairing the osteochondral defect in goat, we designed a double-chamber stirring bioreactor to construct the bone and cartilage composites simultaneously in one β-TCP scaffold and observed the reparative effect in vivo. The osteochondral defects were created in goats and all the animals were divided into 3 groups randomly. In groups A, the defect was treated with the TEO which was cultured with mechanical stimulation of stir; in group B, the defect was treated with TEO which was cultured without mechanical stimulation of stir; in groups C, the defect was treated without TEO. At 12 weeks and 24 weeks after operation, the reparative effects in different groups were assessed and compared. The results indicated that the reparative effect of the TEO cultured in the bioreactor was better than the control group, and mechanical stimulation of stir could further improve the reparative effect. We provided a feasible and effective method to construct the TEO for treatment of osteochondral defect using autologous BMSCs and the double-chamber bioreactor.