China has set a goal of reaching a carbon peak by 2030 and becoming carbon neutral by 2060. Based on the 2050 global energy interconnection (GEI) scenario and backbone grid plan, such issues in the construction of the GEI as high proportion of clean energy, connecting pattern and grid structure, operation control measures, etc. were studied. The proportions of clean energy, implementation path and responding measures to challenges were analysed, the concept of multi-node and multi-loop generalized backbone grid were proposed. The hierarchical and zoning structure was discussed, and intelligent dispatching, stability control, information communication and big data and other operational control measures were proposed. Key technologies such as large-capacity long-distance power transmission, cross-sea power transmission, clean energy power generation, and energy storage were analysed and predicted.