Nature Communications (Sep 2019)

Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production

  • M. Grigalavicius,
  • M. Mastrangelopoulou,
  • K. Berg,
  • D. Arous,
  • M. Ménard,
  • T. Raabe-Henriksen,
  • E. Brondz,
  • S. Siem,
  • A. Görgen,
  • N. F. J. Edin,
  • E. Malinen,
  • T. A. Theodossiou

DOI
https://doi.org/10.1038/s41467-019-12042-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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The authors use accelerated protons on photosensitizers (PS, conventionally excited by light), to generate fluorescence and singlet oxygen which can enhance the efficacy of proton therapy. A pilot study on glioblastoma cells confirms differential cell death upon irradiation in the presence of PS.