Nature Communications (Nov 2017)
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
- Amy S. Farrell,
- Meghan Morrison Joly,
- Brittany L. Allen-Petersen,
- Patrick J. Worth,
- Christian Lanciault,
- David Sauer,
- Jason Link,
- Carl Pelz,
- Laura M. Heiser,
- Jennifer P. Morton,
- Nathiya Muthalagu,
- Megan T. Hoffman,
- Sara L. Manning,
- Erica D. Pratt,
- Nicholas D. Kendsersky,
- Nkolika Egbukichi,
- Taylor S. Amery,
- Mary C. Thoma,
- Zina P. Jenny,
- Andrew D. Rhim,
- Daniel J. Murphy,
- Owen J. Sansom,
- Howard C. Crawford,
- Brett C. Sheppard,
- Rosalie C. Sears
Affiliations
- Amy S. Farrell
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Meghan Morrison Joly
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Brittany L. Allen-Petersen
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Patrick J. Worth
- Department of Surgery, Oregon Health and Science University
- Christian Lanciault
- Department of Pathology, Oregon Health and Science University
- David Sauer
- Department of Pathology, Oregon Health and Science University
- Jason Link
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Carl Pelz
- Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University
- Laura M. Heiser
- Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine, Oregon Health and Science University
- Jennifer P. Morton
- Cancer Research UK, Beatson Institute
- Nathiya Muthalagu
- Cancer Research UK, Beatson Institute
- Megan T. Hoffman
- Department of Molecular and Integrative Physiology, University of Michigan
- Sara L. Manning
- Department of Gastroenterology, Hepatology and Nutrition and Zayed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Unit 1466
- Erica D. Pratt
- Department of Gastroenterology, Hepatology and Nutrition and Zayed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Unit 1466
- Nicholas D. Kendsersky
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Nkolika Egbukichi
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Taylor S. Amery
- Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University
- Mary C. Thoma
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Zina P. Jenny
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- Andrew D. Rhim
- Department of Gastroenterology, Hepatology and Nutrition and Zayed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Unit 1466
- Daniel J. Murphy
- Cancer Research UK, Beatson Institute
- Owen J. Sansom
- Cancer Research UK, Beatson Institute
- Howard C. Crawford
- Department of Molecular and Integrative Physiology, University of Michigan
- Brett C. Sheppard
- Department of Surgery, Oregon Health and Science University
- Rosalie C. Sears
- Department of Molecular and Medical Genetics, Oregon Health and Science University
- DOI
- https://doi.org/10.1038/s41467-017-01967-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poor survival and chemoresistance.
