Frontiers in Oncology (Nov 2024)

Dosimetric scorecards express precise clinical intent: alternate hippocampal-sparing whole-brain RapidPlan models favoring target coverage and homogeneity at 30 and 20 Gy

  • Kareem Rayn,
  • Kareem Rayn,
  • Anthony Magliari,
  • Ryan Clark,
  • Lesley Rosa,
  • Robert Doucet,
  • Line Comeau,
  • Alan Nichol,
  • Russell Ruo,
  • David Roberge

DOI
https://doi.org/10.3389/fonc.2024.1465171
Journal volume & issue
Vol. 14

Abstract

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IntroductionThis study develops two new multi-institutional hippocampal-sparing whole-brain RapidPlan™ models (HLS-EC-WB and HMS-EC-WB) inspired by CCTG-CE.7 featuring enhanced target coverage with varying hippocampal sparing (limited and moderate).MethodsNew dosimetric scorecards were created to quantify the models’ clinical intent. The models were trained using a multi-institution dataset, and a recursive method was employed to generate consistent, high-quality plans. The models were validated using a five-case set and compared at 20- and 30-Gy prescriptions.ResultsEach model scored highest on its associated dosimetric scorecard. The new models achieved higher brain PTV prescription coverage (98%–99%) compared to the previous HSWBv2 model (95.12%), with some trade-off in hippocampal sparing.ConclusionsThree high-quality automated RapidPlan™ models for hippocampal-sparing whole brain are now available, each with a distinct dosimetric scorecard. The new models prioritize increased PTV coverage at some expense to hippocampal sparing. All models, example plans, scorecards, and scoring tools are freely available online.

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