Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases

Zijian Pan; Zijian Pan; Tong Zhu; Tong Zhu; Yanjun Liu; Nannan Zhang

doi:10.3389/fimmu.2022.850998

Frontiers in Immunology (Mar 2022)

Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases

Zijian Pan,
Zijian Pan,
Tong Zhu,
Tong Zhu,
Yanjun Liu,
Nannan Zhang

Affiliations

Zijian Pan: National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
Zijian Pan: West China Hospital of Stomatology, Sichuan University, Chengdu, China
Tong Zhu: National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
Tong Zhu: West China Hospital of Stomatology, Sichuan University, Chengdu, China
Yanjun Liu: National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
Nannan Zhang: National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China

DOI: https://doi.org/10.3389/fimmu.2022.850998
Journal volume & issue: Vol. 13

Abstract

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CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor, CXCR5, CXCL13 plays an important role in lymphoid neogenesis, lymphoid organization, and immune responses. Recent studies have found that CXCL13 and its receptor CXCR5 are implicated in the pathogenesis of several autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, primary Sjögren’s syndrome, myasthenia gravis, and inflammatory bowel disease. In this review, we discuss the biological features of CXCL13 and CXCR5 and the recent findings on the pathogenic roles of the CXCL13/CXCR5 axis in autoimmune diseases. Furthermore, we discuss the potential role of CXCL13 as a disease biomarker and therapeutic target in autoimmune diseases.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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