Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis
Vinicius M. Gadotti,
Graciela Andonegui,
Zizhen Zhang,
Said M'Dahoma,
Cristiane H. Baggio,
Lina Chen,
Lilian Basso,
Christophe Altier,
Wallace K. MacNaughton,
Paul Kubes,
Gerald W. Zamponi
Affiliations
Vinicius M. Gadotti
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Corresponding author
Graciela Andonegui
Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Zizhen Zhang
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Said M'Dahoma
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Cristiane H. Baggio
Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Lina Chen
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Lilian Basso
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Christophe Altier
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Wallace K. MacNaughton
Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Paul Kubes
Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Gerald W. Zamponi
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Corresponding author
Summary: Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases. : Pathophysiology; Behavioral Neuroscience; Cellular Neuroscience; Immunity Subject Areas: Pathophysiology, Behavioral Neuroscience, Cellular Neuroscience, Immunity
