Frontiers in Immunology (Sep 2022)

Autoantibodies in the pathogenesis of idiopathic inflammatory myopathies: Does the endoplasmic reticulum stress response have a role?

  • Esther Guadalupe Corona-Sanchez,
  • Esther Guadalupe Corona-Sanchez,
  • Esther Guadalupe Corona-Sanchez,
  • Erika Aurora Martínez-García,
  • Erika Aurora Martínez-García,
  • Erika Aurora Martínez-García,
  • Andrea Verónica Lujano-Benítez,
  • Andrea Verónica Lujano-Benítez,
  • Oscar Pizano-Martinez,
  • Oscar Pizano-Martinez,
  • Oscar Pizano-Martinez,
  • Ivette Alejandra Guerra-Durán,
  • Efrain Chavarria-Avila,
  • Efrain Chavarria-Avila,
  • Andrea Aguilar-Vazquez,
  • Andrea Aguilar-Vazquez,
  • Beatriz Teresita Martín-Márquez,
  • Beatriz Teresita Martín-Márquez,
  • Kevin Javier Arellano-Arteaga,
  • Juan Armendariz-Borunda,
  • Juan Armendariz-Borunda,
  • Felipe Perez-Vazquez,
  • Ignacio García-De la Torre,
  • Arcelia Llamas-García,
  • Brenda Lucía Palacios-Zárate,
  • Guillermo Toriz-González,
  • Monica Vazquez-Del Mercado,
  • Monica Vazquez-Del Mercado,
  • Monica Vazquez-Del Mercado

DOI
https://doi.org/10.3389/fimmu.2022.940122
Journal volume & issue
Vol. 13

Abstract

Read online

Idiopathic inflammatory myopathies (IIMs) are a group of rare, acquired autoimmune diseases characterized by profound muscle weakness and immune cell invasion into non-necrotic muscle. They are related to the presence of antibodies known as myositis-specific antibodies and myositis-associated antibodies, which are associated with various IIM phenotypes and the clinical prognosis. The possibility of the participation of other pathological mechanisms involved in the inflammatory response in IIM has been proposed. Such mechanisms include the overexpression of major histocompatibility complex class I in myofibers, which correlates with the activation of stress responses of the endoplasmic reticulum (ER). Taking into account the importance of the ER for the maintenance of homeostasis of the musculoskeletal system in the regulation of proteins, there is probably a relationship between immunological and non-immunological processes and autoimmunity, and an example of this might be IIM. We propose that ER stress and its relief mechanisms could be related to inflammatory mechanisms triggering a humoral response in IIM, suggesting that ER stress might be related to the triggering of IIMs and their auto-antibodies’ production.

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