Frontiers in Pediatrics (Mar 2024)
Biomarkers in retinopathy of prematurity: a systematic review and meta-analysis
- Mariam Almutairi,
- Katherine Chechalk,
- Emelia Deane,
- Rebecca Fox,
- Ava Janes,
- Tidgh Maguire-Henry,
- Devin McCabe,
- Cole O'Connor,
- Joseph Quirk,
- Evan Swan,
- Katherine White,
- Kathryn McCreery,
- Eman Isweisi,
- Philip Stewart,
- Aoife Branagan,
- Aoife Branagan,
- Edna F. Roche,
- Edna F. Roche,
- Edna F. Roche,
- Judith Meehan,
- Judith Meehan,
- Judith Meehan,
- Eleanor J. Molloy,
- Eleanor J. Molloy,
- Eleanor J. Molloy,
- Eleanor J. Molloy,
- Eleanor J. Molloy,
- Eleanor J. Molloy,
- Eleanor J. Molloy
Affiliations
- Mariam Almutairi
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Katherine Chechalk
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Emelia Deane
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Rebecca Fox
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Ava Janes
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Tidgh Maguire-Henry
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Devin McCabe
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Cole O'Connor
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Joseph Quirk
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Evan Swan
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Katherine White
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Kathryn McCreery
- Paediatric Ophthalmology, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland
- Eman Isweisi
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Philip Stewart
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Aoife Branagan
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Aoife Branagan
- Paediatrics, Coombe Hospital, Dublin, Ireland
- Edna F. Roche
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Edna F. Roche
- Trinity Research in Childhood Centre (TRiCC), Trinity College Dublin, Dublin, Ireland
- Edna F. Roche
- Endocrinology, Children's Health Ireland (CHI) at Tallaght, Dublin, Ireland
- Judith Meehan
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Judith Meehan
- Trinity Research in Childhood Centre (TRiCC), Trinity College Dublin, Dublin, Ireland
- Judith Meehan
- Trinity College Dublin, Trinity Translational Medicine Institute (TTMI), Trinity Centre for Health Sciences, St James Hospital, The University of Dublin, Dublin, Ireland
- Eleanor J. Molloy
- Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland
- Eleanor J. Molloy
- Paediatrics, Coombe Hospital, Dublin, Ireland
- Eleanor J. Molloy
- Trinity Research in Childhood Centre (TRiCC), Trinity College Dublin, Dublin, Ireland
- Eleanor J. Molloy
- Endocrinology, Children's Health Ireland (CHI) at Tallaght, Dublin, Ireland
- Eleanor J. Molloy
- Trinity College Dublin, Trinity Translational Medicine Institute (TTMI), Trinity Centre for Health Sciences, St James Hospital, The University of Dublin, Dublin, Ireland
- Eleanor J. Molloy
- Neurodisability, Children’s Health Ireland (CHI) at Tallaght, Dublin, Ireland
- Eleanor J. Molloy
- Neonatology, Children's Health Ireland (CHI) at Crumlin, Dublin, Ireland
- DOI
- https://doi.org/10.3389/fped.2024.1371776
- Journal volume & issue
-
Vol. 12
Abstract
AimRetinopathy of prematurity is a significant global cause of childhood blindness. This study aims to identify serum biomarkers that are associated with the development of ROP.MethodsA systematic review and meta-analysis was conducted using PRISMA guidelines. Three databases were searched (Pubmed, Scopus and Web of Science) from 2003 to March 2023. Only studies investigating serum biomarker levels in preterm infants (<37 weeks gestation) were included.ResultsMeta-analysis suggests that low serum IGF-1 levels have a strong association with the development of ROP [SMD (95% CI) of −.46 [−.63, −.30], p < .001]. Meta-analysis suggests that higher serum glucose levels were associated with the development of ROP [SMD (95% CI) of 1.25 [.94, 1.55], p < .001]. Meta-analysis suggests that thrombocytopenia is associated with the development of ROP [SMD (95% CI) of −.62 [−.86, −.37], p < .001].ConclusionLow levels of serum IGF-1, high levels of serum glucose and thrombocytopenia all appear to have the strongest association with the development of ROP out of the 63 biomarkers investigated in this review. These associations highlight their potential use as diagnostic biomarkers in ROP, though further research is needed to establish the exact relationship between these biomarkers and disease pathogenesis.
Keywords
