Cancer Management and Research (Dec 2021)

Clinical and Therapeutic Factors Vary by Prognosis in Patients with Pathological Complete Response After Neoadjuvant Therapy for Breast Cancer

  • Huang Z,
  • Jin S,
  • Zeng M,
  • Shu J,
  • Liu Y,
  • Zhang J,
  • Xu B,
  • Niu M,
  • Sun S,
  • Nanding A,
  • Shan M,
  • Li X,
  • Zhang G

Journal volume & issue
Vol. Volume 13
pp. 9235 – 9246

Abstract

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Zhenfeng Huang,1,* Shiyang Jin,1,* Mengyao Zeng,2,* Jing Shu,1 Yang Liu,1 Jinxing Zhang,1 Bingqi Xu,1 Ming Niu,1 Shanshan Sun,1 Abiyasi Nanding,3 Xiaobo Li,3 Ming Shan,4 Guoqiang Zhang4 1Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, People’s Republic of China; 2Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150081, People’s Republic of China; 3Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, People’s Republic of China; 4 20th Floor Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Shan; Guoqiang Zhang Email [email protected]; [email protected]: To determine clinical predictors of recurrence and metastasis in patients with pathological complete response (pCR) after neoadjuvant chemotherapy (NCT).Methods: Patients treated with NCT who achieved pCR (n=285) were classified into three groups according to pre-NCT clinical stage (cStage): group I (IIa–IIb), group II (IIIa), and group III (IIIb–IIIc). Survival was analysed using the Kaplan–Meier method. The relationships between clinicopathological factors and recurrence were determined using Cox regression analysis.Results: The median follow-up was 31 months. The 3-year disease-free survival and overall survival rates in groups I, II, and III were 92.7%, 87.8%, and 66.7% (P < 0.01) and 98.6%, 98.3%, and 90.6% (P=0.370), respectively. Lymph node status and tumour size were independent risk factors for recurrence and metastasis after NCT. In the human epidermal growth factor receptor 2-positive subgroup, advanced cStage and lymph node metastasis were associated with recurrence (P < 0.01). In the hormone receptor-positive subgroup, disease-free survival rates differed for cStages I–II compared to cStage III (P=0.049) and clinical node status 0– 2 compared to clinical node status 3 (P=0.037).Conclusion: Pre-NCT cStage predicted the prognosis of pCR for different breast cancer subtypes. Patients with advanced cStage, lymph node metastasis, and large tumour sizes had a higher risk of recurrence or metastasis.Keywords: breast cancer, HER2, neoadjuvant chemotherapy, pathological complete response, prognosis

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