TREATMENT OF DIABETIC DISTAL POLYNEUROPATHY WITH ACTOVEGIN® IN TYPE 2 DIABETIC PATIENTS.

Abstract

The possibilities of treatment of diabetic polyneuropathy with Actovegin® are discussed in this publication. In the multicenter, randomized, double-blind trial 567 patients with type 2 diabetes received 20 intravenous infusions of 20% solution of Actovegin® or placebo followed by 1800 mg of Actovegin® in tablets or placebo for 140 days. The effectiveness was assessed by changes of Total Symptom Score and vibration perception as primary outcomes, neuropathy impaired score of the lower limbs (NIS-LL) and quality of life as secondary end points. Treatment with Actovegin resulted in significant improvement in TSS (p = 0,0003), sensory component of NIS-LL (p = 0,021), improvement of vibration perception (р = 0,08) and mental domain of quality of life. Thus, treatment of diabetic distal polyneuropathy with Actovegin® in type 2 diabetic patients improves different functions of peripheral nervs.

Keywords

• diabetes mellitus type 2
• diabetic peripheral polyneuropathy
• treatment with actovegin®