Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

Matthew A. Bedewitz; A. Daniel Jones; John C. D’Auria; Cornelius S. Barry

doi:10.1038/s41467-018-07671-3

Nature Communications (Dec 2018)

Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

Matthew A. Bedewitz,
A. Daniel Jones,
John C. D’Auria,
Cornelius S. Barry

Affiliations

Matthew A. Bedewitz: Department of Horticulture, Michigan State University
A. Daniel Jones: Department of Biochemistry and Molecular Biology, Michigan State University
John C. D’Auria: Department of Chemistry & Biochemistry, Texas Tech University
Cornelius S. Barry: Department of Horticulture, Michigan State University

DOI: https://doi.org/10.1038/s41467-018-07671-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Tropinone is an intermediate in the biosynthesis of tropane alkaloids. Here, the authors discovered the enzymes AbPYKS and AbCYP82M3, a non-canonical polyketide synthase and a cytochrome P450, that work sequentially to form tropinone from N-methyl-Δ1-pyrrolinium cation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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