Acute Toxicity Studies of Aqueous and Ethanol Extracts of Oldenlandia herbacea Roxb. in Albino Rats

Abstract

The present work is to evaluate the acute toxicity of aqueous and ethanol extracts of Oldenlantia herbacea Roxb. in albino rats as per the OECD guidelines. Acute toxicity study of aqueous and ethanol extracts was carried out by administration of 1,3 and 5g/kg bw of Oldenlantia herbacea Roxb. to rats in the respective groups at a single dose. While rats in the control group received 0.5 ml of normal saline. At the end of the experiment, blood samples were collected for hematology and clinical evaluations. Body weight and food consumptions were also noted. The main organs of the body like liver, kidney and lungs were collected for measurement of their weight. In the acute toxicity study of both aqueous and ethanol extracts showed no toxicological signs observed on body weight, organ weight and food consumption of rats. There were no significant changes observed in the liver markers, kidney markers and haematological parameters. From the above findings concluded that aqueous and ethanolic extracts of Oldenlantia herbacea Roxb. at a dose of 1,3 and 5g/kg body weight does not produce any adverse effects and it may be considered as promising therapeutic applications in drug discovery.

Keywords

• acute toxicity
• oldenlantia herbacea roxb.
• oecd
• haematological parameters
• body weight