The gut efflux pump MRP-1 exports oxidized glutathione as a danger signal that stimulates behavioral immunity and aversive learning

Jonathan Lalsiamthara; Alejandro Aballay

doi:10.1038/s42003-022-03381-1

Communications Biology (May 2022)

The gut efflux pump MRP-1 exports oxidized glutathione as a danger signal that stimulates behavioral immunity and aversive learning

Jonathan Lalsiamthara,
Alejandro Aballay

Affiliations

Jonathan Lalsiamthara: Department of Molecular Microbiology and Immunology, School of Medicine, Oregon Health & Science University Portland
Alejandro Aballay: Department of Molecular Microbiology and Immunology, School of Medicine, Oregon Health & Science University Portland

DOI: https://doi.org/10.1038/s42003-022-03381-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The multidrug resistance-associated protein-1 (MRP-1) functions in the basolateral membrane of intestinal cells to transport byproducts of cellular redox reactions to control both molecular and behavioral immunity in C. elegans.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal