Current Directions in Biomedical Engineering (Oct 2021)

Non-destructive analysis of drug distribution in nonwovens as drug-delivery systems for biomedical applications

  • Reske Thomas,
  • Wulf Katharina,
  • Illner Sabine,
  • Eickner Thomas,
  • Grabow Niels,
  • Schmitz Klaus-Peter,
  • Siewert Stefan,
  • Khaimov Valeria

DOI
https://doi.org/10.1515/cdbme-2021-2128
Journal volume & issue
Vol. 7, no. 2
pp. 504 – 506

Abstract

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Analysis of the active ingredient distribution of medical devices is typically performed using Raman spectroscopy, a method that is fast and inexpensive [1]. In addition, it offers the advantage of non-destructive analysis without the need for special sample preparation. Assuming that all components are Raman-active and present in sufficient quantities, their distribution can be well represented. The drug distribution in dexamethasone-loaded polymer nonwovens was investigated in order to draw conclusions on the quality of the fleece batches and to make predictions for the release behavior. In the present study, dexamethasone (DMS), a glucocorticoid was used as the active ingredient. Qualitative and quantitative studies of the content of DMS in polymer films by means of Raman spectroscopy have already been carried out in the working group [2]. A representative square section was examined to describe the distribution of active ingredients. The required number of measurement points (spectra) was determined earlier [2].

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