Nature Communications (Jan 2018)
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
- Rachel Fellows,
- Jérémy Denizot,
- Claudia Stellato,
- Alessandro Cuomo,
- Payal Jain,
- Elena Stoyanova,
- Szabina Balázsi,
- Zoltán Hajnády,
- Anke Liebert,
- Juri Kazakevych,
- Hector Blackburn,
- Renan Oliveira Corrêa,
- José Luís Fachi,
- Fabio Takeo Sato,
- Willian R. Ribeiro,
- Caroline Marcantonio Ferreira,
- Hélène Perée,
- Mariangela Spagnuolo,
- Raphaël Mattiuz,
- Csaba Matolcsi,
- Joana Guedes,
- Jonathan Clark,
- Marc Veldhoen,
- Tiziana Bonaldi,
- Marco Aurélio Ramirez Vinolo,
- Patrick Varga-Weisz
Affiliations
- Rachel Fellows
- Nuclear Dynamics, Babraham Institute
- Jérémy Denizot
- Nuclear Dynamics, Babraham Institute
- Claudia Stellato
- Nuclear Dynamics, Babraham Institute
- Alessandro Cuomo
- Department of Experimental Oncology, Istituto Europeo di Oncologia
- Payal Jain
- Nuclear Dynamics, Babraham Institute
- Elena Stoyanova
- Nuclear Dynamics, Babraham Institute
- Szabina Balázsi
- Nuclear Dynamics, Babraham Institute
- Zoltán Hajnády
- Nuclear Dynamics, Babraham Institute
- Anke Liebert
- Nuclear Dynamics, Babraham Institute
- Juri Kazakevych
- Nuclear Dynamics, Babraham Institute
- Hector Blackburn
- Nuclear Dynamics, Babraham Institute
- Renan Oliveira Corrêa
- Laboratory of Immunoinflammation, Institute of Biology, UNICAMP
- José Luís Fachi
- Laboratory of Immunoinflammation, Institute of Biology, UNICAMP
- Fabio Takeo Sato
- Laboratory of Immunoinflammation, Institute of Biology, UNICAMP
- Willian R. Ribeiro
- Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo
- Caroline Marcantonio Ferreira
- Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo
- Hélène Perée
- Nuclear Dynamics, Babraham Institute
- Mariangela Spagnuolo
- Nuclear Dynamics, Babraham Institute
- Raphaël Mattiuz
- Nuclear Dynamics, Babraham Institute
- Csaba Matolcsi
- Nuclear Dynamics, Babraham Institute
- Joana Guedes
- Lymphocyte Signalling and Development, Babraham Institute
- Jonathan Clark
- Biological Chemistry, Babraham Institute
- Marc Veldhoen
- Lymphocyte Signalling and Development, Babraham Institute
- Tiziana Bonaldi
- Department of Experimental Oncology, Istituto Europeo di Oncologia
- Marco Aurélio Ramirez Vinolo
- Laboratory of Immunoinflammation, Institute of Biology, UNICAMP
- Patrick Varga-Weisz
- Nuclear Dynamics, Babraham Institute
- DOI
- https://doi.org/10.1038/s41467-017-02651-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.
