Transition-Metal-Free One-Pot Synthesis of Fused Benzofuranamines and Benzo[<i>b</i>]thiophenamines

Abstract

A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regioselective five-membered heterocycles were constructed in good-to-excellent yields.

Keywords

• one-pot synthesis
• transition metal-free
• benzofuranamines
• benzo[<i>b</i>]thiophenamines
• C-C coupling