REVERSAL OF TILETAMINE -ZOLAZEPAM - XYLAZINE ANAESTHESIA WITH AMINOPHYLLINE IN DOGS

Abstract

The efficacy of aminophylline as a reversing agent in tiletamine-zolazepamxylazine anaesthesia was studied in 3 groups of dogs. Xylazine (1 mg/kg, i/m) followed by tiletamine-zolazepam (1.25 mg/kg, i/v) was administered to all three groups of animals. In the 2°d and 3`d groups of animals in the middle of anaesthesia, aminophylline at the rate of 20 mg/kg and 40 mg/kg respectively. Aminophylline significantly shortened the time (i) of reappearance of response to tail clamp and skin clamp, (ii) for sternal recumbency, (iii) regaining of righting and (iv) the duration of absence of response to skin clamp and tail clamp and the recovery time. It could be concluded that aminophylline at the dose of 20 mg/kg i/v could be used effectively to reverse anaesthesia produced by tiletaminezolazepam-xylazine combination in dogs.