Haematologica (May 2024)
Continuous and differential improvement in worldwide access to hematopoietic cell transplantation: activity has doubled in a decade with a notable increase in unrelated and non-identical related donors
- Yoshiko Atsuta,
- Helen Baldomero,
- Daniel Neumann,
- Anna Sureda,
- Jakob D. DeVos,
- Minako Iida,
- Amado Karduss,
- Duncan Purtill,
- Alaa M. Elhaddad,
- Nosa G. Bazuaye,
- Carmem Bonfim,
- Rafael de la Camara,
- Naeem A. Chaudhri,
- Fabio Ciceri,
- Cinthya Correa,
- Cristobal Frutos,
- Sebastian Galeano,
- Laurent Garderet,
- Oscar Gonzalez-Ramella,
- Raffaella Greco,
- Nada Hamad,
- Mette D. Hazenberg,
- Mary M. Horowitz,
- Krzysztof Kalwak,
- Bor-Sheng Ko,
- Yoshihisa Kodera,
- Mickey BC Koh,
- Kaiyan Liu,
- Donal P. McLornan,
- Joon Ho Moon,
- Benedicte Neven,
- Shinichiro Okamoto,
- Marcelo C Pasquini,
- Jakob R. Passweg,
- Kristjan Paulson,
- Damiano Rondelli,
- Annalisa Ruggeri,
- Adriana Seber,
- John A. Snowden,
- Alok Srivastava,
- Jeff Szer,
- Daniel Weisdorf,
- Nina Worel,
- Hildegard Greinix,
- Wael Saber,
- Mahmoud Aljurf,
- Dietger Niederwieser
Affiliations
- Yoshiko Atsuta
- Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan; Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute
- Helen Baldomero
- The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital, Basel, CH
- Daniel Neumann
- Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig
- Anna Sureda
- Clinical Hematology Department, Institut Català d'Onvcologia - L'Hospitalet, IDIBELL, Universitat de Barcelona, Barcelona
- Jakob D. DeVos
- Center for International Blood and Marrow Transplant Resaerch, Medical College of Wisconsin, Milwaukee, Wisconsin
- Minako Iida
- Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute
- Amado Karduss
- Instituto de Cancerología-Clínica Las Américas, Medellín, Colombia
- Duncan Purtill
- Haematology Department, Fiona Stanley Hospital, Murdoch, Australia
- Alaa M. Elhaddad
- Department of Pediatric Oncology and Stem Cell Transplantation Unit, Cairo University Cairo, Egypt
- Nosa G. Bazuaye
- Department of Hematology and Blood Transfusion, University of Benin Teaching Hospital, Edo State, Nigeria
- Carmem Bonfim
- Pele Pequeno Principe Research Institute/ Pediatric Blood and Marrow Transplantation Program Hospital Pequeno Principe, Curitiba, Brazil
- Rafael de la Camara
- Hematology Department, Hospital de la Princesa, Madrid
- Naeem A. Chaudhri
- Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
- Fabio Ciceri
- Ospedale San Raffaele s.r.l., Haematology and BMT, Milano
- Cinthya Correa
- Hospital Israelita Albert Eisntein, Sao Paula Brazil
- Cristobal Frutos
- Instituto de Previsión Social, Asunción, Paraguay
- Sebastian Galeano
- Hospital Británico, Montevideo, Uruguay
- Laurent Garderet
- Sorbonne Université, Service d'Hématologie et thérapie cellulaire, HôpitalPitié Salpêtrière, AP-HP, Paris, France
- Oscar Gonzalez-Ramella
- Hospital Civil de Guadalajara, Dr Juan I Menchaca, Guadalajara, Mexico
- Raffaella Greco
- Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Hospital, Milan
- Nada Hamad
- Haematology Clinical Research Unit, St. Vincent's Health Network, Kinghorn Cancer Centre, Sydney, Australia
- Mette D. Hazenberg
- Department of Hematology, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam
- Mary M. Horowitz
- Center for International Blood and Marrow Transplant Resaerch, Medical College of Wisconsin, Milwaukee, Wisconsin
- Krzysztof Kalwak
- Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw
- Bor-Sheng Ko
- Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
- Yoshihisa Kodera
- Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute
- Mickey BC Koh
- Institute for Infection and Immunity St. George's Hospital and Medical School, University of London, London
- Kaiyan Liu
- Department of Hematology, Peking University Institute of Hematology, Beijing
- Donal P. McLornan
- Department of Haematology, University College Hospital, London
- Joon Ho Moon
- Division of Hematology-Oncology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea
- Benedicte Neven
- Service d'immunologie-Hématologie Et Rhumatologie Pédiatrique, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris, INSERM, Paris
- Shinichiro Okamoto
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo
- Marcelo C Pasquini
- Center for International Blood and Marrow Transplant Resaerch, Medical College of Wisconsin, Milwaukee, Wisconsin
- Jakob R. Passweg
- The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital, Basel, CH
- Kristjan Paulson
- Section of Haematology/Oncology, Department of Internal Medicine, Max Rady College of Medicine, the University of Manitoba, Winnipeg, Manitoba, Canada
- Damiano Rondelli
- Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
- Annalisa Ruggeri
- Hematology and BMT Unit, San Raffaele Scientific Institute, Milano
- Adriana Seber
- Department of Medicine, Universidade Federal de Sao Paulo Escola Paulista de Medicina: Sao Paulo, Brazil
- John A. Snowden
- Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
- Alok Srivastava
- Department of Hematology, Christian Medical College Hospital, Vellore
- Jeff Szer
- Clinical Haematology at Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia
- Daniel Weisdorf
- Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota
- Nina Worel
- Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna
- Hildegard Greinix
- Division of Hematology, Medical University of Graz, Graz
- Wael Saber
- Center for International Blood and Marrow Transplant Resaerch, Medical College of Wisconsin, Milwaukee, Wisconsin
- Mahmoud Aljurf
- Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
- Dietger Niederwieser
- Division of Hematology and Medical Oncology, University of Leipzig, Leipzig
- DOI
- https://doi.org/10.3324/haematol.2024.285002
- Journal volume & issue
-
Vol. 999,
no. 1
Abstract
Promoting access to and excellence in hematopoietic cell transplantation (HCT) by collecting and disseminating data on global HCT activities is one of the principal activities of the Worldwide Network for Blood and Marrow Transplantation, a non-Governmental organization in working relations with the World Health Organization. HCT activities are recorded annually by member societies, national registries and individual centers including indication, donor type (allogeneic/autologous), donor match and stem cell source (bone marrow/peripheral blood stem cells/cord blood). In 2018, 1,768 HCT teams in 89 countries (six WHO regions) reported 93,105 (48,680 autologous and 44,425 allogeneic) HCT. Major indications were plasma cell disorders and lymphoma for autologous, and acute leukemias and MDS/MPN for allogeneic HCT. HCT number increased from 48,709 in 2007. Notable increases were seen for autoimmune diseases in autologous and hemoglobinopathies in allogeneic HCT. The number of allogeneic HCT more than doubled with significant changes in donor match. While HCT from HLA identical siblings has seen only limited growth, HCT from non-identical related donors showed significant increase worldwide. Strongest correlation between economic growth indicator of gross national income/capita and HCT activity/ten million population was observed for autologous HCT (r=0.79). HCT from unrelated donors showed strong correlation (r=0.68), but only moderate correlation (r=0.51) was detected from related donors. The use of HCT doubled in about a decade worldwide at different speed and with significant changes regarding donor match as a sign of improved access to HCT worldwide. Although narrowing, significant gaps remain between developing and non-developing countries.
