Medicamentul Veterinar (Jul 2007)
Anthelmintic resistance
Abstract
A thoroughgoing study on resistance was achieved for the first time in insecticides, later on finding that, this can be extended also in anthelmintic substances. The resistance to anthelmintics evolved gradually from a simple medical curiosity, to an important economic problem. Many factors contribute to the appearance of resistance to anthelmintic substances. After epidemiological studies on various helmintic populations, it was concluded that there are four essential and distinguish factors that induce the appearance of parasitic resistance: operational factors, genetic factors, biological and ecological factors. In the last two decades there were conceived many tests to give emphasis to the phenomenon of resistance, but very few were accepted and validated at an international level. The motivation for this phenomenon consist in the fact that every of this methods have a certain sensibility, feasibility and profitableness. All these tests have positive aspects, and few negative aspects, that make themhard to be utilized (apparatus and high costs) or there are not enough sensible, so the obtained results are difficult to be interpreted. The use of molecular technique for the diagnosis of resistance to anthelmintics does not represent a viable option in the present, because the data about the intimate molecular mechanisms of resistance to anthelmintics are very few and there are not confirmed by the clinical reality.
