Nature Communications (Feb 2023)
Identification of a physiologic vasculogenic fibroblast state to achieve tissue repair
- Durba Pal,
- Subhadip Ghatak,
- Kanhaiya Singh,
- Ahmed Safwat Abouhashem,
- Manishekhar Kumar,
- Mohamed S El Masry,
- Sujit K. Mohanty,
- Ravichand Palakurti,
- Yashika Rustagi,
- Saba Tabasum,
- Dolly K. Khona,
- Savita Khanna,
- Sedat Kacar,
- Rajneesh Srivastava,
- Pramod Bhasme,
- Sumit S. Verma,
- Edward Hernandez,
- Anu Sharma,
- Diamond Reese,
- Priyanka Verma,
- Nandini Ghosh,
- Mahadeo Gorain,
- Jun Wan,
- Sheng Liu,
- Yunlong Liu,
- Natalia Higuita Castro,
- Surya C. Gnyawali,
- William Lawrence,
- Jordan Moore,
- Daniel Gallego Perez,
- Sashwati Roy,
- Mervin C. Yoder,
- Chandan K. Sen
Affiliations
- Durba Pal
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Subhadip Ghatak
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Kanhaiya Singh
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Ahmed Safwat Abouhashem
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Manishekhar Kumar
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Mohamed S El Masry
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Sujit K. Mohanty
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Ravichand Palakurti
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Yashika Rustagi
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Saba Tabasum
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Dolly K. Khona
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Savita Khanna
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Sedat Kacar
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Rajneesh Srivastava
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Pramod Bhasme
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Sumit S. Verma
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Edward Hernandez
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Anu Sharma
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Diamond Reese
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Priyanka Verma
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Nandini Ghosh
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Mahadeo Gorain
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Jun Wan
- Center for Computational Biology and Bioinformatics (CCBB), Indiana University School of Medicine
- Sheng Liu
- Center for Computational Biology and Bioinformatics (CCBB), Indiana University School of Medicine
- Yunlong Liu
- Center for Computational Biology and Bioinformatics (CCBB), Indiana University School of Medicine
- Natalia Higuita Castro
- Department of Biomedical Engineering, The Ohio State University
- Surya C. Gnyawali
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- William Lawrence
- Department of Surgery, The Ohio State University
- Jordan Moore
- Department of Surgery, The Ohio State University
- Daniel Gallego Perez
- Department of Surgery, The Ohio State University
- Sashwati Roy
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Mervin C. Yoder
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- Chandan K. Sen
- Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36665-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
Here, the authors report on the discovery of physiological vasculogenic fibroblasts capable of forming functional blood vessels. In vivo tissue reprogramming triggered by topical tissue nanotransfection (TNT) of a single anti-miR-200b oligonucleotide achieved therapeutic tissue vascularization.
