Jounal of Negative and No Positive Results (Jun 2016)

The relation between plasmatic triglycerides levels and polymorphisms -133T>C and 56C>G of ApoA5 codifying gene

  • Ismael San Mauro Martín,
  • Ana María Ruiz León,
  • Elena Garicano Vilar,
  • Javier Andrés Blumenfeld Olivares,
  • Eva Pérez Arruche,
  • Esperanza Arce Delgado,
  • María José Ciudad Cabañas,
  • Luis Collado Yurrita

DOI
https://doi.org/10.19230/jonnpr.2016.1.1.932
Journal volume & issue
Vol. 1, no. 1
pp. 31 – 35

Abstract

Read online

Aim. The aim was to evaluate the association between polymorphisms -113C>T (rs662799) and 56C>G (rs3135506) and plasmatic triglycerides levels in adults. Methods. A randomized clinical trial of 44 subjects from two hospital centers from Madrid (Spain). Anthropometric survey, blood test genetic analysis and an Ad hoc survey (lifestyle habits: nutrition, physical activity, sleep) were conducted. Results. No statistically significant differences were observed between polymorphism 113G>T or 56C>G and plasmatic triglycerides concentrations (p>0.05). However, statistically significant differences were found between gene variant 56C>G and total cholesterol levels and low-density lipoproteins (p=0.015 and p=0.036, respectively). Conclusion. This trial brings to light no association between plasmatic triglycerides levels and polymorphic variants 56C>G and - 1131T>C of Apo5 coding gene.

Keywords