Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases

Taiyu Shang; Tianyi Jiang; Xiaowen Cui; Yufei Pan; Xiaofan Feng; Liwei Dong; Hongyang Wang

Genes and Diseases (Jul 2024)

Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases

Taiyu Shang,
Tianyi Jiang,
Xiaowen Cui,
Yufei Pan,
Xiaofan Feng,
Liwei Dong,
Hongyang Wang

Affiliations

Taiyu Shang: School of Life Sciences, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China
Tianyi Jiang: National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China; International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai 200438, China
Xiaowen Cui: National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China
Yufei Pan: National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China
Xiaofan Feng: National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China; International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai 200438, China
Liwei Dong: National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China; International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai 200438, China; Corresponding author. National Center for Liver Cancer, the Naval Medical University, Shanghai 201805, China.
Hongyang Wang: School of Life Sciences, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China; National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China; International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai 200438, China; Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Second Military Medical University & Ministry of Education, Shanghai 200438, China; Corresponding author. School of Life Sciences, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China.

Journal volume & issue: Vol. 11, no. 4
p. 100996

Abstract

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The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities. The hepatobiliary system originates from the foregut endoderm, in which cells undergo multiple events of cell proliferation, migration, and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription factors. Studies on liver development and diseases have revealed that SRY-related high-mobility group box 9 (SOX9) plays an important role in liver embryogenesis and the progression of hepatobiliary diseases. SOX9 is not only a master regulator of cell fate determination and tissue morphogenesis, but also regulates various biological features of cancer, including cancer stemness, invasion, and drug resistance, making SOX9 a potential biomarker for tumor prognosis and progression. This review systematically summarizes the latest findings of SOX9 in hepatobiliary development, homeostasis, and disease. We also highlight the value of SOX9 as a novel biomarker and potential target for the clinical treatment of major liver diseases.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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