Hemorrhagic polypoid lesion on the leg - eccrine porocarcinoma: A case report

Abstract

Eccrine porocarcinoma is a rarely seen cutaneous malignancy originating from the intraepidermal ductus of eccrine glands. The disease is characterized by nodular lesions primarily located in the lower extremities. The disease may arise de novo or develop from the background of eccrine poroma. Differential diagnoses of eccrine porocarcinoma include various benign and malignant skin conditions such as seborrheic keratosis, verruca, pyogenic granuloma, and squamous cell carcinoma. The histopathological analysis is essential to diagnosis, and dermoscopic imaging of lesions is significant. Eccrine differentiation, cellular pleomorphism, nuclear atypia, invasion in the histopathological examination; carcinoembryonic antigen and epithelial membrane antigen positivity in immunohistochemical study guides the diagnosis. Eccrine porocarcinoma may spread through lymphatic vessels, and therefore it is essential to perform regional lymph node examination and use appropriate imaging methods in patients. The main treatment option for eccrine porocarcinoma is wide surgical excision with clean margins, and excision can be curative in 80% of patients.

Keywords

• eccrine
• porocarcinoma
• dermoscopy
• dermatopathology