Nature Communications (Sep 2020)

Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

  • Lisa Prendergast,
  • Urszula L. McClurg,
  • Rossitsa Hristova,
  • Rolando Berlinguer-Palmini,
  • Sarah Greener,
  • Katie Veitch,
  • Inmaculada Hernandez,
  • Philippe Pasero,
  • Daniel Rico,
  • Jonathan M. G. Higgins,
  • Anastas Gospodinov,
  • Manolis Papamichos-Chronakis

DOI
https://doi.org/10.1038/s41467-020-18306-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

Read online

In mammalian cells, during transcription and replication, RNA:DNA hybrid structures known as R-loops can arise, posing as obstacles to replication fork progression. Here the authors reveal that the ATP-dependent chromatin remodelling INO80 complex promotes resolution of R-loops to prevent replication associated DNA damage in cancer cells.