Diabetes, Metabolic Syndrome and Obesity (Aug 2021)
Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
Abstract
Jing Zhao,1,2,* Yinbiao Su,3,* Jin-An Zhang,2 Ming Fang,4 Xuerong Liu,2 Xi Jia,2 Xinming Li1,4 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China; 3Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, 201508, People’s Republic of China; 4Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinming LiGraduate School, Shanghai University of Traditional Chinese Medicine, Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of ChinaTel +86 21-68135590-3160Email [email protected]: To investigate the relationship between iodine intake status and the prevalence of metabolic syndrome (MetS) through a population-based survey.Patients and Methods: In total, 2691 Chinese adults participated in this cross-sectional study, and they were stratified by urinary iodine concentration (UIC) and sex. Fasting blood samples were used to assess biochemical parameters, including thyroid function and antibodies. Urine samples were collected in the morning to measure UIC. Multivariate regression logistic analysis was performed for the overall population and sex subgroups.Results: An inverse association was observed between iodine intake status and MetS prevalence in Chinese adults. Compared with individuals with adequate iodine status, those with high-iodine status had significantly low MetS risks, and the adjusted odds ratios (95% confidence interval) were 0.70 (0.57– 0.86, P 0.05).Conclusion: An inverse association was observed between iodine intake status and the risk of developing MetS in Chinese adults. Sufficient iodine status is a potential protective factor for MetS development. Males may benefit from increased iodine intake, while females would need to achieve a more-than-adequate iodine status to gain metabolic benefits.Keywords: dyslipidemia, hypertension, hyperglycemia, abdominal obesity
