Communications Biology (Jun 2022)
Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia
- Domenico Lo Tartaro,
- Anita Neroni,
- Annamaria Paolini,
- Rebecca Borella,
- Marco Mattioli,
- Lucia Fidanza,
- Andrew Quong,
- Carlene Petes,
- Geneve Awong,
- Samuel Douglas,
- Dongxia Lin,
- Jordan Nieto,
- Licia Gozzi,
- Erica Franceschini,
- Stefano Busani,
- Milena Nasi,
- Anna Vittoria Mattioli,
- Tommaso Trenti,
- Marianna Meschiari,
- Giovanni Guaraldi,
- Massimo Girardis,
- Cristina Mussini,
- Lara Gibellini,
- Andrea Cossarizza,
- Sara De Biasi
Affiliations
- Domenico Lo Tartaro
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Anita Neroni
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Annamaria Paolini
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Rebecca Borella
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Marco Mattioli
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Lucia Fidanza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Andrew Quong
- Fluidigm Corporation
- Carlene Petes
- Fluidigm Corporation
- Geneve Awong
- Fluidigm Corporation
- Samuel Douglas
- Fluidigm Corporation
- Dongxia Lin
- Fluidigm Corporation
- Jordan Nieto
- Fluidigm Corporation
- Licia Gozzi
- Infectious Diseases Clinics, AOU Policlinico di Modena
- Erica Franceschini
- Infectious Diseases Clinics, AOU Policlinico di Modena
- Stefano Busani
- Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia
- Milena Nasi
- Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia
- Anna Vittoria Mattioli
- Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia
- Tommaso Trenti
- Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics, AUSL/AOU Policlinico
- Marianna Meschiari
- Infectious Diseases Clinics, AOU Policlinico di Modena
- Giovanni Guaraldi
- Infectious Diseases Clinics, AOU Policlinico di Modena
- Massimo Girardis
- Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia
- Cristina Mussini
- Infectious Diseases Clinics, AOU Policlinico di Modena
- Lara Gibellini
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Andrea Cossarizza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Sara De Biasi
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-03537-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
Patients over the age of 70 show inflammaging and a weaker anti-viral response to SARS-CoV-2, pointing at the immunological changes associated with COVID-19 severity and outcome for aged patients.
