Human beige adipocytes for drug discovery and cell therapy in metabolic diseases

Amar M. Singh; Liang Zhang; John Avery; Amelia Yin; Yuhong Du; Hui Wang; Zibo Li; Haian Fu; Hang Yin; Stephen Dalton

doi:10.1038/s41467-020-16340-3

Nature Communications (Jun 2020)

Human beige adipocytes for drug discovery and cell therapy in metabolic diseases

Amar M. Singh,
Liang Zhang,
John Avery,
Amelia Yin,
Yuhong Du,
Hui Wang,
Zibo Li,
Haian Fu,
Hang Yin,
Stephen Dalton

Affiliations

Amar M. Singh: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia
Liang Zhang: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia
John Avery: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia
Amelia Yin: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia
Yuhong Du: Department of Pharmacology and Chemical Biology, Emory Chemical Biology Discovery Center, Emory University School of Medicine
Hui Wang: Department of Radiology, Biomedical Research Imaging Center, University of North Carolina Chapel Hill
Zibo Li: Department of Radiology, Biomedical Research Imaging Center, University of North Carolina Chapel Hill
Haian Fu: Department of Pharmacology and Chemical Biology, Emory Chemical Biology Discovery Center, Emory University School of Medicine
Hang Yin: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia
Stephen Dalton: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia

DOI: https://doi.org/10.1038/s41467-020-16340-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic development relating to metabolic diseases such as type 2 diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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