Nature Communications (Jul 2020)

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs

  • Arvind Kumar,
  • Sandip Basak,
  • Shanlin Rao,
  • Yvonne Gicheru,
  • Megan L. Mayer,
  • Mark S. P. Sansom,
  • Sudha Chakrapani

DOI
https://doi.org/10.1038/s41467-020-17364-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Glycinergic synapses play a central role in motor control and pain processing in the central nervous system. Here, authors present cryo-EM structures of the full-length glycine receptors (GlyRs) reconstituted into lipid nanodiscs in the unliganded, glycine-bound and allosteric modulator-bound conformations and reveal global conformational changes underlying GlyR channel gating and modulation.