Nature Communications (Aug 2022)
Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis
- Mostafa Bakhti,
- Aimée Bastidas-Ponce,
- Sophie Tritschler,
- Oliver Czarnecki,
- Marta Tarquis-Medina,
- Eva Nedvedova,
- Jessica Jaki,
- Stefanie J. Willmann,
- Katharina Scheibner,
- Perla Cota,
- Ciro Salinno,
- Karsten Boldt,
- Nicola Horn,
- Marius Ueffing,
- Ingo Burtscher,
- Fabian J. Theis,
- Ünal Coskun,
- Heiko Lickert
Affiliations
- Mostafa Bakhti
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Aimée Bastidas-Ponce
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Sophie Tritschler
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Oliver Czarnecki
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Marta Tarquis-Medina
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Eva Nedvedova
- German Center for Diabetes Research (DZD)
- Jessica Jaki
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Stefanie J. Willmann
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Katharina Scheibner
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Perla Cota
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Ciro Salinno
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Karsten Boldt
- Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen
- Nicola Horn
- Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen
- Marius Ueffing
- Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen
- Ingo Burtscher
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Fabian J. Theis
- Institute of Computational Biology, Helmholtz Zentrum München
- Ünal Coskun
- German Center for Diabetes Research (DZD)
- Heiko Lickert
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- DOI
- https://doi.org/10.1038/s41467-022-31862-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
How pancreatic islets of Langerhans are built during development is incompletely understood. Here the authors find that Synaptotagmin-13 mediates remodeling of cell-matrix adhesion to regulate endocrine cell egression and islet morphogenesis.
