Combating increased antifungal drug resistance in                     Cryptococcus, what should we do in the future?

Deng Hengyu; Song Jialin; Huang Yemei; Yang Chen; Zang Xuelei; Zhou Yangyu; Li Hongli; Dai Bin; Xue Xinying

doi:10.3724/abbs.2023011

Acta Biochimica et Biophysica Sinica (Feb 2023)

Combating increased antifungal drug resistance in Cryptococcus, what should we do in the future?

Deng Hengyu,
Song Jialin,
Huang Yemei,
Yang Chen,
Zang Xuelei,
Zhou Yangyu,
Li Hongli,
Dai Bin,
Xue Xinying

Affiliations

Deng Hengyu: ["Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261053, China"]
Song Jialin: ["Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261053, China"]
Huang Yemei: ["of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China"]
Yang Chen: ["Department of Laboratory Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China"]
Zang Xuelei: ["of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China"]
Zhou Yangyu: ["of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China"]
Li Hongli: ["Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261053, China"]
Dai Bin: ["of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China"]
Xue Xinying: ["Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261053, China","of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China"]

DOI: https://doi.org/10.3724/abbs.2023011
Journal volume & issue: Vol. 55
pp. 540 – 547

Abstract

Read online

Few therapeutic drugs and increased drug resistance have aggravated the current treatment difficulties of Cryptococcus in recent years. To better understand the antifungal drug resistance mechanism and treatment strategy of cryptococcosis. In this review, by combining the fundamental features of Cryptococcus reproduction leading to changes in its genome, we review recent research into the mechanism of four current anti-cryptococcal agents, coupled with new therapeutic strategies and the application of advanced technologies WGS and CRISPR-Cas9 in this field, hoping to provide a broad idea for the future clinical therapy of cryptococcosis.

Published in Acta Biochimica et Biophysica Sinica

ISSN: 1672-9145 (Print); 1745-7270 (Online)
Publisher: China Science Publishing & Media Ltd.
Country of publisher: China
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General): Genetics
Website: https://www.sciengine.com/ABBS/home

About the journal

Abstract

Keywords