Construction of highly congested quaternary carbon centers by NHC catalysis through dearomatization

Lixia Liu; Cong-Ying Zhou; Chengming Wang

Green Synthesis and Catalysis (Aug 2023)

Construction of highly congested quaternary carbon centers by NHC catalysis through dearomatization

Lixia Liu,
Cong-Ying Zhou,
Chengming Wang

Affiliations

Lixia Liu: College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China
Cong-Ying Zhou: Corresponding authors.; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China
Chengming Wang: Corresponding authors.; College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China

Journal volume & issue: Vol. 4, no. 3
pp. 263 – 267

Abstract

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A NHC-catalyzed hypervalent iodine reagents and transition-metal free redox-neutral dearomatization of phenols is reported. This protocol provides an efficient access for highly congested quaternatry carbon centers construction. It also features operationally simplicity, mild reaction conditions and good functional group tolerance. Moreover, the reported procedure can be easily emplified to 1 g scale. Mechanism study reveals the dearomative transformation possibly undergoes a single electron transfer process with NHC radical cation as a reactive intermediate.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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