Formulation and Evaluation of Cefotaxime Sodium Loaded Emulgel for Topical Bacterial Infections

Abstract

The bacterial infections are very common and become a serious issue like in case of infections of one and more reproductive organ, inflammation on protective membrane of brain and spinal cord, inflammation of lungs air sacs, body drainage system infections, problem in body’s extreme response and infection caused by sexually transmitted bacteria in male and female. Generally, these bacterial infections are treated by using antibiotics like cefotaxime that is a semisynthetic, β-lactamase resistant, third-generation broad-spectrum cephalosporin. The common side effects of cefotaxime are uneasiness of stomach before vomiting, sneezing, itching. The topical antibacterial dosage forms like creams, gel, and ointment have some demerits and low duration of drug release. The emulgel is an alternative for topical drug delivery with several merits like enhanced skin penetration and improved bioavailability, reduced dosing, improved patient acceptability with targeted drug delivery, freedom of termination of the therapy at any time, drug delivery in controlled fashion for prolong duration. The aim of study was to develop a biphasic promising drug delivery system emulgel of cefotaxime. The 23 experimental design was used to prepare various emulgel batches to determinant the effect of liquid paraffin, span 20 and tween 20 on the performance of emulgel. The Batch F1 showed the maximum drug release while batch F8 up to 240 minutes. The drug release kinetics study of Batch F8 showed the Higuchi-Matrix as a best fit model and the Fickian Diffusion as a mechanism of drug release with R2 value 0.9158 and K value 8.4741.

Keywords

• antibiotics
• carbopol
• cefotaxime
• cephalosporin
• emulgel
• topical
• delivery