Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans

PingHsun Hsieh; Vy Dang; Mitchell R. Vollger; Yafei Mao; Tzu-Hsueh Huang; Philip C. Dishuck; Carl Baker; Stuart Cantsilieris; Alexandra P. Lewis; Katherine M. Munson; Melanie Sorensen; AnneMarie E. Welch; Jason G. Underwood; Evan E. Eichler

doi:10.1038/s41467-021-25435-4

Nature Communications (Aug 2021)

Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans

PingHsun Hsieh,
Vy Dang,
Mitchell R. Vollger,
Yafei Mao,
Tzu-Hsueh Huang,
Philip C. Dishuck,
Carl Baker,
Stuart Cantsilieris,
Alexandra P. Lewis,
Katherine M. Munson,
Melanie Sorensen,
AnneMarie E. Welch,
Jason G. Underwood,
Evan E. Eichler

Affiliations

PingHsun Hsieh: Department of Genome Sciences, University of Washington School of Medicine
Vy Dang: Department of Genome Sciences, University of Washington School of Medicine
Mitchell R. Vollger: Department of Genome Sciences, University of Washington School of Medicine
Yafei Mao: Department of Genome Sciences, University of Washington School of Medicine
Tzu-Hsueh Huang: Department of Genome Sciences, University of Washington School of Medicine
Philip C. Dishuck: Department of Genome Sciences, University of Washington School of Medicine
Carl Baker: Department of Genome Sciences, University of Washington School of Medicine
Stuart Cantsilieris: Department of Genome Sciences, University of Washington School of Medicine
Alexandra P. Lewis: Department of Genome Sciences, University of Washington School of Medicine
Katherine M. Munson: Department of Genome Sciences, University of Washington School of Medicine
Melanie Sorensen: Department of Genome Sciences, University of Washington School of Medicine
AnneMarie E. Welch: Department of Genome Sciences, University of Washington School of Medicine
Jason G. Underwood: Department of Genome Sciences, University of Washington School of Medicine
Evan E. Eichler: Department of Genome Sciences, University of Washington School of Medicine

DOI: https://doi.org/10.1038/s41467-021-25435-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Duplications of gene segments can allow novel physiological adaptations to evolve. A detailed analysis of the TCAF gene family in primates and archaic humans suggest rapid duplication and diversification in this gene family is associated with cold or dietary adaptations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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