BMJ Open (Nov 2024)
Cohort profile: the WHO Child Mortality Risk Stratification Multi-Country Pooled Cohort (WHO-CMRS) to identify predictors of mortality through early childhood
- ,
- Fyezah Jehan,
- Niranjan Kissoon,
- Jerome Kabakyenga,
- Kenneth Brown,
- Nigel Rollins,
- Mustafa Mahfuz,
- Tahmeed Ahmed,
- Sunil Sazawal,
- Rajiv Bahl,
- Marko Kerac,
- Ameena Goga,
- Venkata Raghava Mohan,
- Audrey Prost,
- Sheila Isanaka,
- Wafaie Fawzi,
- Christopher Duggan,
- Tor A Strand,
- Rasheda Khanam,
- Alemayehu Argaw,
- Carl Lachat,
- Indi Trehan,
- Sengchanh Kounnavong,
- Moses Ngari,
- Ali Saleem,
- Jean-Bosco Ouedraogo,
- Natasha Lelijveld,
- Dongqing Wang,
- Marie McGrath,
- Jeanette Bailey,
- James A Berkley,
- Andrew Prentice,
- Sophie Moore,
- Laeticia Celine Toe,
- Lieven Huybregts,
- Judd L Walson,
- Ranadip Chowdhury,
- Geeta Trilok-Kumar,
- Denise Evans,
- Ezekiel Mupere,
- Agnès Le Port,
- Yasir Bin Nisar,
- Mark Manary,
- Marie Ruel,
- Matthew Wiens,
- Siri Kaldenbach,
- Imran Nisar,
- Abdullah Baqui,
- Lacey LaGrone,
- Karim P Manji,
- Rebecca Grais,
- Wieger Voskuijl,
- Ousmane Guindo,
- Dominique Roberfroid,
- Benson Singa,
- Catherine Schwinger,
- Elodie Becquey,
- Jay A Berkley,
- Mohammed Jobayer Chisti,
- Hama A Diallo,
- Md. Alfazal Khan,
- David Hamer,
- Sonja Hess,
- Patrick Kabore,
- Jef Leroy,
- Sam Marconi,
- Nathan Kenya Mugisha,
- Shalton Mwaringa,
- Sindhu Kulandaipalayam Natarajan,
- Deanna Olney,
- Peter Rockers,
- Heather Stobaugh,
- Molly Timbwa,
- Waseem Ali
Affiliations
- Fyezah Jehan
- Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
- Niranjan Kissoon
- British Columbia Children`s Hospital, Vancouver, British Columbia, Canada
- Jerome Kabakyenga
- 7 Maternal, Newborn, and Child Health Institute, Mbarara University of Science and Technology, Mbarara, Uganda
- Kenneth Brown
- 1 Department of Nutrition, University of California Davis, Davis, California, USA
- Nigel Rollins
- Department of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva, GE, Switzerland
- Mustafa Mahfuz
- Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
- Tahmeed Ahmed
- Nutrition Research Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
- Sunil Sazawal
- Center for Public Health Kinetics, New Delhi, India
- Rajiv Bahl
- Department of Medicine, World Health Organization, Geneva, Switzerland
- Marko Kerac
- Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK
- Ameena Goga
- HIV and Other Infectious Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa
- Venkata Raghava Mohan
- 1 Christian Medical College Vellore, Vellore, Tamil Nadu, India
- Audrey Prost
- University College London Institute of Child Health, London, UK
- Sheila Isanaka
- 1 Department of Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA
- Wafaie Fawzi
- Department of Global Health and Population, Harvard School of Public Health, Boston, Massachusetts, USA
- Christopher Duggan
- Center for Nutrition, Boston Children’s Hospital, Boston, Massachusetts, USA
- Tor A Strand
- Department for Global Public Health and Primary Care, Centre for International Health, Universitetet i Bergen, Bergen, Norway
- Rasheda Khanam
- International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
- Alemayehu Argaw
- Department of Food Technology, Safety and Health, Ghent University, Gent, Belgium
- Carl Lachat
- Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Gent, Belgium
- Indi Trehan
- 1 Department of Global Health, University of Washington, Seattle, Washington, USA
- Sengchanh Kounnavong
- Lao Tropical and Public Health Institute, Vientiane, Lao People`s Democratic Republic
- Moses Ngari
- 1 Clinical Research Department, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
- Ali Saleem
- 1 Department of Pediatrics & Child Health, The Aga Khan University, Karachi, Sindh, Pakistan
- Jean-Bosco Ouedraogo
- Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso
- Natasha Lelijveld
- Emergency Nutrition Network, Kidlington, UK
- Dongqing Wang
- Global and Community Health, George Mason University College of Health and Human Services, Fairfax, Virginia, USA
- Marie McGrath
- Emergency Nutrition Network, Kidlington, UK
- Jeanette Bailey
- Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK
- James A Berkley
- 1 Clinical Research Department, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
- Andrew Prentice
- St Mark’s Bowel Cancer Screening Centre, London North West Healthcare NHS Trust, Harrow, UK
- Sophie Moore
- Department of Women and Children`s Health, King`s College London, London, UK
- Laeticia Celine Toe
- Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Gent, Belgium
- Lieven Huybregts
- Poverty, Health and Nutrition Division, International Food Policy Research Institute, Washington, DC, USA
- Judd L Walson
- Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
- Ranadip Chowdhury
- Society for Applied Studies, New Delhi, India
- Geeta Trilok-Kumar
- 3Institute of Home Economics, University of Delhi, Delhi, India
- Denise Evans
- Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- Ezekiel Mupere
- Agnès Le Port
- Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France
- Yasir Bin Nisar
- Department of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneve, Switzerland
- Mark Manary
- adjunct associate professor
- Marie Ruel
- International Food Policy Research Institute, Washington, District of Columbia, USA
- Matthew Wiens
- Center for International Child Health, BC Children`s Hospital, Vancouver, British Columbia, Canada
- Siri Kaldenbach
- Department of Research, Sykehuset Innlandet HF, Lillehammer, Norway
- Imran Nisar
- Biorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Sindh, Pakistan
- Abdullah Baqui
- International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
- Lacey LaGrone
- Department of Surgery, UCHealth, Loveland, Colorado, USA
- Karim P Manji
- Department of Paediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania
- Rebecca Grais
- 4 Department of Research, Epicentre, Paris, France
- Wieger Voskuijl
- Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands
- Ousmane Guindo
- Epicentre, Paris, France
- Dominique Roberfroid
- Benson Singa
- Centre for Public Health Kinetics (CPHK), Delhi, India
- Catherine Schwinger
- Department for Global Public Health and Primary Care, Centre for International Health, Universitetet i Bergen, Bergen, Norway
- Elodie Becquey
- Jay A Berkley
- Mohammed Jobayer Chisti
- Hama A Diallo
- Md. Alfazal Khan
- David Hamer
- Sonja Hess
- Patrick Kabore
- Jef Leroy
- Sam Marconi
- Nathan Kenya Mugisha
- Shalton Mwaringa
- Sindhu Kulandaipalayam Natarajan
- Deanna Olney
- Peter Rockers
- Heather Stobaugh
- Molly Timbwa
- Waseem Ali
- DOI
- https://doi.org/10.1136/bmjopen-2024-085164
- Journal volume & issue
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Vol. 14,
no. 11
Abstract
Purpose To provide details of a pooled data set that will be used to estimate absolute and relative mortality risks and other outcomes among children less than 59 months of age and the predictive performance of common risk exposures, both individually and in combination.Participants Children from birth to 5 years of age recruited at health facilities or community settings into 33 longitudinal observational or intervention studies in 17 low- and middle-income countries.Findings to date The data set includes 75 287 children with a median age of 3 months (IQR 1–12) at first measurement. In the pooled sample, 2805 (3.7%) of the study children died. Data on birth weight was recorded in 19 studies, and gestational age in 13 studies. Among these, 14% of the included children were reported as having low birth weight, and 14% had preterm birth. At first measurement, 33% of the children were stunted, 24% were wasted and 35% underweight. 13% and 7% of caregivers reported that their child had acute diarrhoea or acute lower respiratory tract infection before the study visit, respectively. The proportion of children reported as breastfed at any study visit decreased from 99% at age <6 months to 77% in the age group 12–23 months. Child characteristics differed considerably between studies in the community and healthcare settings. The median study period was 15 months (IQR 7.6–18.4 months).Future plans Planned analyses will examine knowledge gaps with the aim of informing global guidelines and their derivatives such as clinical management tools and implementation guidance, and to inform future research agendas. We aim to estimate absolute mortality risks associated with child age, anthropometry, birth characteristics and feeding practices as planned by the WHO-Risk Stratification Working Group. In the future, other data sets may be added and further questions on survival and growth will be investigated.
