Hormonal-metabolic profile in menopausal women with insomnia

Abstract

25-54 % of menopausal women have sleep problems that significantly reduces the quality of life. The aim of the review was to analyze the literature about the hormonal-metabolic profile of menopausal women with sleep disorders. It was shown that brain serotonergic systems are disrupted, melatonin production and activity of free-radical oxidation of lipids are altered in women with insomnia. This may lead to the development of different diseases.

Keywords

• insomnia
• menopause
• melatonin
• oxidative stress