Treatment with <i>Terminalia chebula</i> Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats

Abstract

Background: Terminalia chebula Retz., Family Combretaceae (T. chebula) is one of the important plants mentioned in Ayurveda, a traditional system of medicine. The present work was designed to study the effect of the aqueous extract of T. chebula fruits in type 2 diabetic rats. Methods: The aqueous extract of the fruits was prepared by the double maceration technique. The extract was subjected to HPTLC analysis, which showed the presence of ellagic acid and gallic acid. Type 2 diabetes was induced in rats with a low dose of Streptozotocin (35 mg/kg) after administering a high-fat diet for fourteen days. Diabetic animals were treated with 500 and 1000 mg/kg of aqueous extract of T. chebula fruits for six weeks. Results: Diabetic rats showed a significantly (511.7 ± 17.6) (p T. chebula treatment group showed a significant (p p p p p T. chebula aqueous extract at 1000 mg/kg significantly increased the level of GSH (p T. chebula treatment at 1000 mg/kg significantly increased levels of CAT (p T. chebula has significant effects in the management of type 2 diabetes.

Keywords

• <i>Terminalia chebula</i>
• insulin resistance
• tannins
• type 2 diabetes
• hyperglycemia
• high-fat diet