Development and evaluation of drug delivery patch for topical wound healing application

Abstract

Abstract Wound treatment remains a challenge to many clinicians because of the complexities of the wound healing process. With the astonishing progress of biomedical engineering during the past few decades, conventional drug delivery systems have been evolved into smart drug delivery systems with stimuli-responsive characteristics. The objective of this study was to develop and evaluate an electromechanically actuated drug dispensation device which can release active pharmaceutical compound in a controlled fashion. Additive manufacturing was employed to design and fabricate the device. Haptic technology was used to provide stimulation for drug release, and Cicatrin was used to evaluate the drug release patterns of device. Drug release study was comprised of in vitro drug release, static study, and the purpose of this study was to develop a compliance chart for different wound conditions. The effectiveness of shortlisted drug regimen from compliance chart was validated through microbial study and animal studies. The results of animal studies were compared with commercially available drug release systems. The results of drug release studies gave different dose regimens for different wound conditions. The effective dose regimen was able to create 1-cm-wide microbial zone of inhibitions. The wound healing rate of mice for commercially available release system for five consecutive days was 10%, 10%, 20%, 40% and 50% and for test device was 10%, 30%, 60%, 90% and 100%. Hence, the device proved its effectiveness and efficacy of dosage regimen for wound healing applications through in vitro, microbial and in vivo studies. In conclusion, this device proved to be an accurate and specific drug delivery system with improved medication and therapeutic outcomes for personalized medication.

Keywords

• Smart bandage
• Drug delivery
• Topical wounds
• Chronic wounds
• 3D printing