Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

Xiangqi Meng; Yu Zhao; Bo Han; Caijun Zha; Yangong Zhang; Ziwei Li; Pengfei Wu; Tengfei Qi; Chuanlu Jiang; Yang Liu; Jinquan Cai

doi:10.1038/s41467-019-14036-x

Nature Communications (Jan 2020)

Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

Xiangqi Meng,
Yu Zhao,
Bo Han,
Caijun Zha,
Yangong Zhang,
Ziwei Li,
Pengfei Wu,
Tengfei Qi,
Chuanlu Jiang,
Yang Liu,
Jinquan Cai

Affiliations

Xiangqi Meng: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Yu Zhao: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University
Bo Han: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Caijun Zha: Department of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University
Yangong Zhang: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Ziwei Li: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Pengfei Wu: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Tengfei Qi: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Chuanlu Jiang: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Yang Liu: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University
Jinquan Cai: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences

DOI: https://doi.org/10.1038/s41467-019-14036-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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