Nature Communications (Jun 2021)
Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
Abstract
G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determine cell-specific transcriptional programs.