Nature Communications (Jun 2021)

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

  • Sara Lago,
  • Matteo Nadai,
  • Filippo M. Cernilogar,
  • Maryam Kazerani,
  • Helena Domíniguez Moreno,
  • Gunnar Schotta,
  • Sara N. Richter

DOI
https://doi.org/10.1038/s41467-021-24198-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determine cell-specific transcriptional programs.