Medial temporal lobe functional connectivity predicts stimulation-induced theta power

E. A. Solomon; J. E. Kragel; R. Gross; B. Lega; M. R. Sperling; G. Worrell; S. A. Sheth; K. A. Zaghloul; B. C. Jobst; J. M. Stein; S. Das; R. Gorniak; C. S. Inman; S. Seger; D. S. Rizzuto; M. J. Kahana

doi:10.1038/s41467-018-06876-w

Nature Communications (Oct 2018)

Medial temporal lobe functional connectivity predicts stimulation-induced theta power

E. A. Solomon,
J. E. Kragel,
R. Gross,
B. Lega,
M. R. Sperling,
G. Worrell,
S. A. Sheth,
K. A. Zaghloul,
B. C. Jobst,
J. M. Stein,
S. Das,
R. Gorniak,
C. S. Inman,
S. Seger,
D. S. Rizzuto,
M. J. Kahana

Affiliations

E. A. Solomon: Department of Bioengineering, University of Pennsylvania
J. E. Kragel: Department of Psychology, University of Pennsylvania
R. Gross: Department of Neurosurgery, Emory School of Medicine
B. Lega: Department of Neurosurgery, University of Texas Southwestern
M. R. Sperling: Department of Neurology, Thomas Jefferson University Hospital
G. Worrell: Department of Neurology, Department of Physiology and Bioengineering, Mayo Clinic
S. A. Sheth: Department of Neurosurgery, Baylor College of Medicine
K. A. Zaghloul: Surgical Neurology Branch, National Institutes of Health
B. C. Jobst: Department of Neurology, Dartmouth Medical Center
J. M. Stein: Department of Radiology, Hospital of the University of Pennsylvania
S. Das: Department of Radiology, Hospital of the University of Pennsylvania
R. Gorniak: Department of Radiology, Thomas Jefferson University Hospital
C. S. Inman: Department of Neurosurgery, Emory School of Medicine
S. Seger: Department of Neurosurgery, University of Texas Southwestern
D. S. Rizzuto: Department of Psychology, University of Pennsylvania
M. J. Kahana: Department of Psychology, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-018-06876-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Direct electrical brain stimulation can induce widespread changes in neural activity, offering a means to modulate network-wide activity and treat disease. Here, the authors show that the low-frequency functional connectivity profile of a stimulation target predicts where induced theta activity occurs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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