Nature Communications (May 2021)

Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

  • Anais Julien,
  • Anuya Kanagalingam,
  • Ester Martínez-Sarrà,
  • Jérome Megret,
  • Marine Luka,
  • Mickaël Ménager,
  • Frédéric Relaix,
  • Céline Colnot

DOI
https://doi.org/10.1038/s41467-021-22842-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Bone regeneration involves activation of tissue resident stem cells. Here the authors show that mesenchymal progenitors from skeletal muscle mediate the fibrotic response to bone injury and also contribute to bone repair; processes that are impaired when both muscle and bone are injured.