Nature Communications (Jan 2018)
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
- Guermarie Velazquez-Torres,
- Einav Shoshan,
- Cristina Ivan,
- Li Huang,
- Enrique Fuentes-Mattei,
- Harrison Paret,
- Sun Jin Kim,
- Cristian Rodriguez-Aguayo,
- Victoria Xie,
- Denise Brooks,
- Steven J. M. Jones,
- A. Gordon Robertson,
- George Calin,
- Gabriel Lopez-Berenstein,
- Anil Sood,
- Menashe Bar-Eli
Affiliations
- Guermarie Velazquez-Torres
- Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer Center
- Einav Shoshan
- Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer Center
- Cristina Ivan
- Department of Gynecologic Oncology, Unit 1362, The University of Texas MD Anderson Cancer Center
- Li Huang
- Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer Center
- Enrique Fuentes-Mattei
- Department of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer Center
- Harrison Paret
- Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer Center
- Sun Jin Kim
- Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer Center
- Cristian Rodriguez-Aguayo
- Department of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer Center
- Victoria Xie
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Denise Brooks
- Canada’s Michael Smith Cancer Agency
- Steven J. M. Jones
- Canada’s Michael Smith Cancer Agency
- A. Gordon Robertson
- Canada’s Michael Smith Cancer Agency
- George Calin
- Department of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer Center
- Gabriel Lopez-Berenstein
- Department of Experimental Therapeutics, Unit 1950, The University of Texas MD Anderson Cancer Center
- Anil Sood
- Department of Gynecologic Oncology, Unit 1362, The University of Texas MD Anderson Cancer Center
- Menashe Bar-Eli
- Department of Cancer Biology, Unit 1906, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-02851-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 7
Abstract
In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.
