Nature Communications (Mar 2017)
Endocannabinoid signalling modulates susceptibility to traumatic stress exposure
- Rebecca J. Bluett,
- Rita Báldi,
- Andre Haymer,
- Andrew D. Gaulden,
- Nolan D. Hartley,
- Walker P. Parrish,
- Jordan Baechle,
- David J. Marcus,
- Ramzi Mardam-Bey,
- Brian C. Shonesy,
- Md. Jashim Uddin,
- Lawrence J. Marnett,
- Ken Mackie,
- Roger J. Colbran,
- Danny G. Winder,
- Sachin Patel
Affiliations
- Rebecca J. Bluett
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Rita Báldi
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Andre Haymer
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Andrew D. Gaulden
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Nolan D. Hartley
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Walker P. Parrish
- Department of Molecular Physiology & Biophysics, Vanderbilt University Medical Center
- Jordan Baechle
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- David J. Marcus
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Ramzi Mardam-Bey
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Brian C. Shonesy
- Department of Molecular Physiology & Biophysics, Vanderbilt University Medical Center
- Md. Jashim Uddin
- A.B. Hancock Jr. Memorial Laboratory for Cancer Research and Vanderbilt Institute of Chemical Biology
- Lawrence J. Marnett
- A.B. Hancock Jr. Memorial Laboratory for Cancer Research and Vanderbilt Institute of Chemical Biology
- Ken Mackie
- Department of Psychological and Brain Sciences, Indiana University
- Roger J. Colbran
- The Vanderbilt Brain Institute, Vanderbilt University Medical Center
- Danny G. Winder
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- Sachin Patel
- Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/ncomms14782
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Understanding inter-individual differences in stress-susceptibility could lead to novel treatments and preventative strategies for stress-related pathologies. Here the authors provide evidence that increased endocannabinoid signalling is a resilience factor that buffers against adverse consequences of stress.
