Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy

Abstract

Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.

Keywords

• autophagy
• celastrol
• mitochondria
• mitophagy
• nur77
• p62/sqstm1
• traf2