Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

Karen Perez de Arce; Adema Ribic; Dhrubajyoti Chowdhury; Katherine Watters; Garth J. Thompson; Basavaraju G. Sanganahalli; Elizabeth T. C. Lippard; Astrid Rohlmann; Stephen M. Strittmatter; Markus Missler; Fahmeed Hyder; Thomas Biederer

doi:10.1038/s41467-023-36042-w

Nature Communications (Jan 2023)

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

Karen Perez de Arce,
Adema Ribic,
Dhrubajyoti Chowdhury,
Katherine Watters,
Garth J. Thompson,
Basavaraju G. Sanganahalli,
Elizabeth T. C. Lippard,
Astrid Rohlmann,
Stephen M. Strittmatter,
Markus Missler,
Fahmeed Hyder,
Thomas Biederer

Affiliations

Karen Perez de Arce: Department of Neuroscience, Tufts University School of Medicine
Adema Ribic: Department of Neuroscience, Tufts University School of Medicine
Dhrubajyoti Chowdhury: Department of Neurology, Yale School of Medicine
Katherine Watters: Department of Neuroscience, Tufts University School of Medicine
Garth J. Thompson: Department of Radiology and Biomedical Imaging, Yale School of Medicine
Basavaraju G. Sanganahalli: Department of Radiology and Biomedical Imaging, Yale School of Medicine
Elizabeth T. C. Lippard: Department of Radiology and Biomedical Imaging, Yale School of Medicine
Astrid Rohlmann: Institute of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-University
Stephen M. Strittmatter: Department of Neurology, Yale School of Medicine
Markus Missler: Institute of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-University
Fahmeed Hyder: Department of Radiology and Biomedical Imaging, Yale School of Medicine
Thomas Biederer: Department of Neuroscience, Tufts University School of Medicine

DOI: https://doi.org/10.1038/s41467-023-36042-w
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

Read online

LRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for cognitive function in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal