Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica

Yongshuo Ma; Nian Liu; Per Greisen; Jingbo Li; Kangjian Qiao; Sanwen Huang; Gregory Stephanopoulos

doi:10.1038/s41467-022-28277-w

Nature Communications (Jan 2022)

Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica

Yongshuo Ma,
Nian Liu,
Per Greisen,
Jingbo Li,
Kangjian Qiao,
Sanwen Huang,
Gregory Stephanopoulos

Affiliations

Yongshuo Ma: Department of Chemical Engineering, Massachusetts Institute of Technology
Nian Liu: Department of Chemical Engineering, Massachusetts Institute of Technology
Per Greisen: Global Research, Novo Nordisk A/S
Jingbo Li: Department of Chemical Engineering, Massachusetts Institute of Technology
Kangjian Qiao: Department of Chemical Engineering, Massachusetts Institute of Technology
Sanwen Huang: Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
Gregory Stephanopoulos: Department of Chemical Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-28277-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Substrate inhibition has not been widely studied in the context of synthetic biology and metabolic engineering. Here, the authors report removal of lycopene substrate inhibition by two different strategies and enable high carotenoid productivity in Yarrowia lipolytica.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal