Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block

Abstract

Abstract Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and maintained, resulting in sustained complete response for POEMS syndrome.

Keywords

• AV block
• bortezomib
• heart block
• POEMS syndrome