Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells

Wei Chen; Pingting Liu; Dong Liu; Haoliang Huang; Xue Feng; Fang Fang; Liang Li; Jian Wu; Liang Liu; David E. Solow-Cordero; Yang Hu

doi:10.1038/s41467-022-34682-y

Nature Communications (Nov 2022)

Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells

Wei Chen,
Pingting Liu,
Dong Liu,
Haoliang Huang,
Xue Feng,
Fang Fang,
Liang Li,
Jian Wu,
Liang Liu,
David E. Solow-Cordero,
Yang Hu

Affiliations

Wei Chen: Department of Ophthalmology, Stanford University School of Medicine
Pingting Liu: Department of Ophthalmology, Stanford University School of Medicine
Dong Liu: Department of Ophthalmology, Stanford University School of Medicine
Haoliang Huang: Department of Ophthalmology, Stanford University School of Medicine
Xue Feng: Department of Ophthalmology, Stanford University School of Medicine
Fang Fang: Department of Ophthalmology, Stanford University School of Medicine
Liang Li: Department of Ophthalmology, Stanford University School of Medicine
Jian Wu: Department of Ophthalmology, Stanford University School of Medicine
Liang Liu: Department of Ophthalmology, Stanford University School of Medicine
David E. Solow-Cordero: High-Throughput Bioscience Center, Stanford University School of Medicine
Yang Hu: Department of Ophthalmology, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34682-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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ER stress is associated with various neurodegenerative diseases. This study found that FDA approved drug, maprotiline, inhibits histamine receptor H1-mediated ER stress and provides significant neuroprotection in mouse glaucoma model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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